Autologous Versus Allogeneic Adipose-Derived Mesenchymal Stem Cell Therapy for Knee Osteoarthritis: A Systematic Review, Pairwise and Network Meta-Analysis of Randomized Controlled Trials
Knee osteoarthritis (OA) is a degenerative joint disorder with limited non-surgical treatment options. Adipose-derived mesenchymal stem cell (AD-MSC) therapy has emerged as a promising regenerative approach; however, the comparative efficacy and safety of autologous versus allogeneic AD-MSCs remain unclear. This systematic review and network meta-analysis (NMA) evaluated the effectiveness and safety of intra-articular AD-MSCs in adults with Kellgren-Lawrence Grade II-IV knee OA
Intraarticular leukocyte-poor platelet-rich plasma injection is more effective than intraarticular hyaluronic acid injection in the treatment of knee osteoarthritis: a systematic review and meta-analysis of 12 randomized controlled trials
We aim to compare the clinical effects of intraarticular leukocyte-poor platelet-rich plasma (LP-PRP) injection with those of intraarticular hyaluronic acid (HA) injection in adult patients with knee osteoarthritis.
Rotator Cuff Tendinopathy Diagnosis, Nonsurgical Medical Care, and Rehabilitation: A Clinical Practice Guideline
This evidence-based clinical practice guideline (CPG) aims to guide clinicians with recommendations covering the assessment, treatment, and prognosis of adults with shoulder pain with suspected rotator cuff (RC) tendinopathy, the nonsurgical medical care and rehabilitation of adults with RC tendinopathy, as well as the return to function and sport for elite and recreational athletes.
Understanding the Causes of Knee Pain on the Outer (Lateral) Part of Your Knee
An injury or arthritis most likely causes pain outside the knee. A doctor can determine the cause based on your other symptoms and the results of imaging tests.
Expert Advice on Bilateral Knee Replacement
Orthopedic surgeons perform almost 700,000 knee replacements in the United States each year, and the procedure has a high success rate in alleviating pain and restoring an active lifestyle. It’s not uncommon for patients to have arthritis in both knees, so they may need to decide, along with their surgeon, whether to have both knees replaced at the same time. This procedure, known as a bilateral knee replacement (or double knee replacement), has both pros and cons.
Urgent Care is available after hours and weekends through Ortho Care on Demand.
